Tuesday, January 18, 2011

Alcohol and Our Body - Some Facts


01. Alcohol  specifically ethanol (ethyl alcohol) is the most socially-accepted addictive drug which can have life-threatening health hazards.

02. Health benefits are frequently claimed for alcohol - when consumed in "moderation". Most of the claimed benefits are associated with reducing cardiovascular disease.


03. Modest doses of ethanol beneficially increases plasma HDL cholesterol and reduces blood pressure while harmfully raising plasma triglycerides, decreasing heart muscle contractility and increasing heart rate. Heavier drinking increases blood pressure. 

 

04. For diabetics, ethanol may produce atherosclerosis at all doses in a direct dose-dependent fashion.


05. Reduced clotting is another benefit of light ethanol consumption - an effect ethanol shares with aspirin. And as with aspirin, with less clotting there is less chance of coronary artery disease, but a greater danger of hemorrhagic stroke.


06. Use of ethanol has been associated with higher risk of mortality from hypertension, hemorrhagic stroke and cardiomyopathy.

07. Ethanol reacts with fatty acids to produce fatty acid ethyl esters which are toxic to mitochondria - leading to heart muscle cell damage.
 
08. Ethanol impairment of protein synthesis affects both skeletal and heart muscle. In isolated heart cells ethanol reduces the number & uniformity of fibrils (minute fibers). 

09. Studies have shown that for people who are lean and active, HDL cholesterol is not lowered with ethanol. 

10. Ethanol can increase liver concentrations of CYP2E1 up to tenfold. Induction of CYP2E1 by ethanol may be a significant contributer to alcohol induced liver diseas.

11. Heavy drinking can lead to triglyceride accumulation - fatty liver.

12. Protein deficiency increases liver damage due to ethanol.  

13. The cancer rate in alcoholics is ten times higher than that in the general population.

14. Every 10 grams (10 ml) per day of ethanol consumption is associated with a 9% increase in breast cancer .

15. Both acute & chronic ethanol consumption increases serum estrogen and decreases serum androgen in both men & women.

16. Many alcoholic men have irreversible atrophy of their testicles.

17. The combination of ethanol, cigarette smoking seems to have a powerful synergistic effect in oral, pharyngeal cancer.

18. Ethanol is known to reduce T-cells (Thymus-derived lymphocytes) - suppression of the immune system that can increase cancer incidence and decrease resistance to infectious disease.

19. Ethanol may also suppress DNA methylation of oncogenes (cancer-inducing genes) leading to dedifferentiation & proliferation. 

20. Other mechanisms suggested for increased incidence of cancer with ethanol include effects on liver carcinogen metabolism, generation of free-radicals, depression of DNA-repair, reduced nutrients due to reduced absorption and reduced consumption of food nutrients associated with obtaining calories from alcohol.

21. Both acute and chronic alchohol consumption can suppress the immune system, leading to increased susceptibility to infections. Decreased antigen-presenting cell function appears to be the most important factor in reduced cell-mediated immunity.

22. Ethanol stimulates excess levels of plasma cortisol, which can have harmful immunosuppressant and anabolic consequences.

23. Alcohol damages energy-generating systems of mitochondria, while at the same time increasing metabolism.

24. Ethanol stimulates acid-rich gastric secretions, making alcohol consumption inadvisable for patients with peptic ulcers. 

25. Ethanol interferes with the metabolism of oral hypoglycemics (such as tolbutamide) taken by some diabetics.

26. Asthma is worsened by alcoholic beverages for nearly a third of asthmatics. 

27. Aspirin & ethanol are not a good combination. Taken together they significantly worsen bleeding time (hemorrhagic stroke), gastric irritation and foetal brain damage.

28. The risk of spinal osteoporosis with vertebral fractures is significantly greater among men who drink alcoholic beverages than those who don't. 

29. Small amounts of alcohol can increase the sex drive of men, while at the same time reducing their capacity to get an erection.

30. 10-15% of alcoholics experience peripheral neuropathy, causing numbness & tingling.

31. Studies of all-cause mortality show a linear relationship between alcohol consumption and death below the age of 60.

32. Driving under the influence of alcohol is the most important cause of death in automobile accidents.

33. For non-motor vehicle accidents, ethanol intoxication accounted for 32% of fatal falls, 42% of fatal fires/burns, 34% of fatal drownings and 29% of fatal poisonings. 32% of homicide victims and 23% of suicide victims were intoxicated.

34. Ethanol is implicated in up to half of all cases of marital violence.

35. Hangovers result from blockage of AntiDiuretic Hormone (ADH) by alcohol, which leads to high urination and subsequent dehydration.The symptoms are throbbing head (due to reduced cranial blood pressure), dry mouth, lethargy, nausea and hypersensitivity to light & sound.

36. Medical authorities typically suggest total abstinence from ethanol for those who have uncontrolled high blood pressure, substantially elevated triglycerides, liver disease, gastrointestinal ulcers and alcoholic myopathy. 

37. Ethanol is also contraindicated for patients on many medications, including antihistamines such as diphenhydramine (Benadryl), tricyclic antidepressants such as amitriptyline (Elavil), and antianxiety drugs such as alprazolam (Xanax) and lorazepam (Ativan). 

38. There is reason to believe that ethanol might have some benefit for coronary heart disease for those with high blood LDL cholesterol. But the benefit can usually be achieved more safely by other means of lowering LDL cholesterol. 

39. There is a significant risk of birth defects related to use of alcohol use during pregnancy. Heavy drinking can cause fetal alcohol syndrome, which prevents normal growth, and may cause intellectual disability (mental retardation), malformations of the skull and face, and other findings.

40. There is no known benefit of alcohol use during pregnancy. Thus, experts advise completely avoiding alcohol during pregnancy.

41. Alcohol abuse is associated with an increased risk of suicide.


So Think Twice,
Before you Drink.

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17 comments:

  1. (നബിയേ,) നിന്നോടവര്‍ മദ്യത്തെയും ചൂതാട്ടത്തെയും പറ്റി ചോദിക്കുന്നു. പറയുക: അവ രണ്ടിലും ഗുരുതരമായ പാപമുണ്ട്‌. ജനങ്ങള്‍ക്ക് ചില പ്രയോജനങ്ങളുമുണ്ട്‌. എന്നാല്‍ അവയിലെ പാപത്തിന്റെ അംശമാണ് പ്രയോജനത്തിന്റെ അംശത്തേക്കാള്‍ വലുത്‌. എന്തൊന്നാണവര്‍ ചെലവ് ചെയ്യേണ്ടതെന്നും അവര്‍ നിന്നോട് ചോദിക്കുന്നു. നീ പറയുക: (അത്യാവശ്യം കഴിച്ച്‌) മിച്ചമുള്ളത്‌. അങ്ങനെ ഇഹപര ജീവിതങ്ങളെപ്പറ്റി നിങ്ങള്‍ ചിന്തിക്കുവാന്‍ വേണ്ടി അല്ലാഹു നിങ്ങള്‍ക്ക് തെളിവുകള്‍ വിവരിച്ചുതരുന്നു.[2:219]

    ReplyDelete
  2. എന്റെ മാന്യ ശുഹ്ര്തെ തങ്ങളുടെ പോസ്റ്റ്‌ ഞാന്‍ ഒരു പ്രതീക്ഷയോടെ തുറന്നു പക്ഷെ ഞാന്‍ നിരാശനായി മടങ്ങി പോകുന്നു

    അക്ഷരകൂട്ടങ്ങളുമായി സഹവാസം കുറഞ്ഞ ഈ പമാരന് അങ്ങ്ലെയം കുറേ വരകള്‍ മാത്രം

    ReplyDelete
  3. enthu patti changaathee....
    enikkonnum manassilaayilla...

    ReplyDelete
  4. enikk english ariyilla athaa paranjath

    ReplyDelete
  5. friday/saturday evening without a drink.. naaa naaaa...

    ReplyDelete
  6. Absar Bhai...Nice article... In this article, it has came in to my view that alcohol consumption may cause AIDS.. how could be it possible..could u please explain the same as it is a new infmn to me.

    And off-course, this article contains a lot of infmn rather than we know. I think such kind of articles must be published in your blog frequently.. will be useful either to the readers and patients .

    Best wishes..

    ReplyDelete
    Replies
    1. The harmful use of alcohol is also associated with several infectious diseases like HIV/AIDS, tuberculosis and sexually transmitted infections (STIs). This is because alcohol consumption weakens the immune system.

      A study by Gregory J. Bagby at the Louisiana State University Health Sciences Center found that alcohol consumption may increase host susceptibility to HIV infection.
      Bagby's student, conducted with rhesus monkeys infected with simian immunodeficiency virus (SIV), found that in the early stages of infection, monkeys who were given alcohol to drink had 64 times the amount of virus in their blood than the control monkeys. Bagby concluded that the alcohol increased infectivity of cells or increased the number of susceptible cells.

      For people who have already been infected with HIV, drinking alcohol can also may accelerate their HIV disease progression, according to a study by Jeffrey H. Samet at Boston University. The reason for this is both HIV and alcohol suppress the body's immune system.

      Delete
  7. good .............snehaashamsakalode punyavaalan

    ReplyDelete
  8. അബ്സാര്‍ ബായ്, ലേഖനം നന്നായി,
    എനിക്ക് തോന്നുന്നത് വെള്ളമൊഴിച്ച് അടിച്ചാല്‍ ഇത്ര ഹാനികരം ആവില്ലെന്നാണ് ..

    ReplyDelete
    Replies
    1. ഓരോരോ തോന്നലുകള്‍ :)

      Delete
    2. Choodaattam engane paapamaakunnu?onnarinjaal kollam..,

      Delete
  9. അബ്സാര്‍ ,മദ്യപാനം,പാപം ആണെന്നും ,മദ്യപാനി പാപി ആണെന്നും ഉള്ള ധാരണ മാറ്റി ...ഇതൊരു രോഗം ആണെന്നും ,കുടിയന്‍ അല്ക്കഹോളിസം എന്ന രോഗം ബാധിച്ചവന്‍ ആണ് എന്ന തിരിച്ചറിവ് സമൂഹത്തില്‍ ഉണ്ടായാലേ ...മദ്യപാനിയെ ഈ അസുഖത്തില്‍ നിന്നും ,രക്ഷപെടുത്താന്‍ ആകൂ ..

    ReplyDelete
  10. i don`t know ,how to use my ID for this purpose...that`s why in both article i cmntd as anonymous

    ReplyDelete
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